Clinical Trials Open to Healthy Volunteers

A “healthy volunteer” is someone who doesn't have any major health problems, and takes part in research to test new medicines, devices, or treatments. UC Irvine offers clinical trials on a wide range of medical conditions. Healthy volunteers can help UC Irvine researchers make better comparisons to better understand the treatment of diseases.

• Acupressure in Patients With Sickle Cell Disease

  • study on Sickle Cell Anemia and Anemia
  • open to healthy people ages 14-80

• Adherence to Vaginal Estrogen Therapy in Hypoestrogenic Women With Recurrent Urinary Tract Infections

  • study on Urinary Tract Infection and Hypoestrogenism
  • open to healthy females ages 18 years and up

• Alzheimer's Disease Neuroimaging Initiative 4

  • study on Mild Cognitive Impairment and Alzheimer's Disease
  • open to healthy people ages 55-90

• Anticoagulation Profile in Pregnant Women Treated with Three Times a Day of Low Molecular Weight Heparin (LMWH)

  • study on Pregnancy and Anticoagulants
  • open to healthy females ages 18 years and up

• ASSESS ALL ALS Study

  • study on Amyotropic Lateral Sclerosis (ALS) and Acute Lymphoblastic Leukemia
  • open to healthy people ages 18 years and up

• Biomarker Exploration in Aging, Cognition and Neurodegeneration

  • study on Alzheimer's Disease and Cognitive Impairment
  • open to healthy people ages 60 years and up

• Cardiac-Control Affecting Learning Through Mindfulness (CALM)

  • study on Cognitive Decline and Alzheimer's Disease
  • open to healthy people ages 50-70

• Characterization of Inclusion Body Myopathy Associated With Paget's Disease of Bone and Frontotemporal Dementia (IBMPFD)

  • study on Dementia and Frontotemporal Dementia
  • open to healthy people ages 18 years and up

• Childhood Cancer Survivor Study

  • study on Cancer, General
  • open to healthy people

• Clinical and Genetic Evaluation of Individuals With Undiagnosed Disorders Through the Undiagnosed Diseases Network

  • open to healthy people ages 1 month to 100 years

• Conscious Pregnancy: Supporting Maternal Cardiometabolic Health With Mindfulness

  • study on Maternal Cardiometabolic Health and Mental Health
  • open to healthy females ages 18 years and up

• Continuous Monitoring and Management of Vaginal Health Via Multifunctional OCT/OCTA/OCE Endoscopy

  • study on Menopause
  • open to healthy females ages 18 years and up

• Dementia Family Caregiver Study

  • study on Caregivers and Dementia
  • open to healthy people ages 18 years and up

• DEXA-C Anterior Cervical Interbody System

  • study on Degenerative Disc Disease
  • open to healthy people ages 18 years and up

• Empowering Hispanic Patients' Lung Cancer Screening Uptake (Empower Latinx)

  • study on Lung Cancer and Cancer, General
  • open to healthy people ages 50-80

• Energy Healing in Fibromyalgia

  • study on Fibromyalgia
  • open to healthy females ages 18-75

• Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort

  • study on Huntington's Disease
  • open to healthy people ages 18 years and up

• Ethnic Influences on Stress, Energy Balance and Obesity in Adolescents

  • study on Obesity and Mental Health
  • open to healthy females ages 13-17

• Evaluate Multi-Spectral and Laser Speckle Imaging and Multiphoton Microscopy During Vascular Occlusion

  • study on Abnormal Vascular Flow
  • open to healthy people ages 18 years and up

• Exercise in Child Health

  • study on Cystic Fibrosis and Fibrosis
  • open to healthy people ages 10-17

• Exploring, Predicting, and Intervening on Long-term Viral Suppression Electronically

  • study on HIV/AIDS
  • open to healthy people ages 18 years and up

• Imaging-based Assessment of Oral Biofilm and Gingival Health

  • study on Dental Plaque and Gingivitis
  • open to healthy people ages 18 years and up

• In-vivo Non-invasive Skin Imaging Using Multiphoton Microscopy

  • study on Skin Lesion
  • open to healthy people

• Latinx Children and Surgery

  • study on Postoperative Pain and Pain
  • open to healthy people ages 2-7

• Mouthrinse on the Microbiome of the Oral Cavity and GI Tract

  • study on Oral Bacterial Infection and Oral Infection
  • open to healthy people ages 18 years and up

• Nicotine to Reverse Age-related Auditory Processing Deficits

  • study on Auditory Perceptual Impairment and Nicotine
  • open to healthy people ages 18-85

• Optical Coherence Tomography Guided Laser Treatment of Basal Cell Carcinoma

  • study on Basal Cell Carcinoma and Carcinoma
  • open to healthy people ages 18-99

• Optical Sensor for Photodynamic Detection of Oral Pathology

  • study on Mouth Diseases
  • open to healthy people ages 18-75

• PK and PD of ABX1100

  • study on Pompe Disease
  • open to healthy people ages 18 years and up

• Positive Affect Treatment for Adolescents with Early Life Adversity

  • study on Depression
  • open to healthy people ages 12-16

• Role of Angiogenesis in Dermatologic Diseases: A Potential Therapeutic Target

  • study on Dermatologic Diseases
  • open to healthy people ages 16 years and up

• Skin Imaging With Technologies in Development

  • study on Pigmented Skin Lesion of Uncertain Nature
  • open to healthy people ages 7 years and up

• Taletrectinib Phase 2 Global Study in ROS1 Positive NSCLC

  • study on Lung Cancer and Non-Small Cell Lung Cancer
  • open to healthy people ages 18 years and up

• The Actuate-CBC Study

  • study on Telehealth
  • open to healthy people ages 18 years and up

• THRIVE Study: Teaching Healthy Regulation in Individuals & Vulnerable Environments

  • study on Adverse Childhood Experiences and Family Functioning
  • open to healthy people ages 11-14

• Vaginal Changes After CO2 Laser

  • study on Menopause
  • open to healthy females ages 18 years and up

• Women Informed to Screen Depending on Measures of Risk (Wisdom Study)

  • study on Breast Cancer and Cancer, General
  • open to healthy females ages 30-74

Current as of: July 21, 2025