for people ages 12-16 (full criteria)
Healthy Volunteers
healthy people welcome
at Irvine, California
study started
completion around
Principal Investigator
by Kate R Kuhlman



Youth exposed to early life adversity (ELA) are known to be at greater risk for depression and suicidality and account for almost half of the youth suffering from psychiatric diseases today. Youth exposed to ELA consistently report symptoms of anhedonia as well as dysregulated positive affect. The present project will test the efficacy of PAT in a sample of ELA-exposed adolescents in order to determine whether PAT increases positive affect, and subsequently symptoms of depression. For this pilot, the investigators will recruit 22 adolescents exposed to two or more childhood adversities (ACEs) who do not currently have major depressive disorder, and randomize them (1:1) to either participate in PAT or a waitlist control condition. At study enrollment, then 4-, 8, and 12-months thereafter the investigators will measure positive affect and depressive symptoms (including anhedonia). The results of this study will be used to inform whether PAT has the potential to prevent major depressive episodes among adversity-exposed youth.

Official Title

Mitigating Depression Among Adversity Exposed Adolescents Using Positive Affect Therapy


Depression, Positive affect treatment


You can join if…

Open to people ages 12-16

  • aged 12-16
  • exposed to 2 or more adverse childhood experiences (ACEs)

You CAN'T join if...

  • currently taking an antidepressant or any medications known to influence immune functioning on a daily basis (e.g., steroidal medications to treat asthma or allergies)
  • current or past history of manic or psychotic symptoms
  • parent-reported diagnosis of intellectual disability or autism spectrum disorder
  • chronic medical conditions (e.g., cancer, rheumatoid arthritis, diabetes, multiple sclerosis),
  • bleeding disorders such as hemophilia


  • University of California Irvine accepting new patients
    Irvine California 92617 United States

Lead Scientist at UC Irvine


accepting new patients
Start Date
Completion Date
University of California, Irvine
Study Type
Expecting 22 study participants
Last Updated