for people ages 50-70 (full criteria)
Healthy Volunteers
healthy people welcome
study started
completion around



Some types of meditation lead heart rate to become more steady as breathing quiets whereas others lead to large heart rate swings up and down (oscillations) as breathing becomes deeper and slower. The current study is designed to investigate how daily practice of heart rate biofeedback during breathing in a pattern that either increases or decreases heart rate oscillation affect attention and memory and blood biomarkers associated with Alzheimer's disease.

Official Title

Heartrate and Breathing Effects on Attention and Memory Main Study


Age-related Cognitive Decline, Alzheimer Disease, Cognitive Dysfunction, Daily practice, Increase Oscillation, Decrease Oscillation


You can join if…

Open to people ages 50-70

  • self identify as Black/African-American or White/European-American
  • aged 50-70
  • normal or corrected-to-normal vision and hearing
  • speak English fluently
  • have an email account checked regularly
  • have a phone that receives text messages
  • willing to provide a blood sample and a urine sample at two lab visits
  • willing to devote up to 60 minutes daily to the study for 10 weeks (in addition to lab visits)

You CAN'T join if...

  • cardiac pacemaker
  • frequent cardiac arrhythmias
  • cognitive impairment
  • currently practice any meditation, biofeedback or breathing technique for more than an hour per week
  • have regularly played Lumosity games in the past six months
  • participated in a previous heart rate variability (HRV) biofeedback study
  • have any conditions listed below that are not safe for magnetic resonance imaging (MRI) Claustrophobia Have worked as a machinist, metal worker, or in any profession or hobby grinding metal Have had an injury to the eye involving a metallic object (e.g., metallic slivers, shavings, or foreign body) Implanted cardiac defibrillator Aneurysm clip or brain clip Carotid artery vascular clamp Neurostimulator Insulin or infusion pump Spinal fusion stimulator Cochlear, otologic, ear tubes or ear implant Prosthesis (eye/orbital, penile, etc.) Implant held in place by a magnet Heart valve prosthesis Electrodes (on body, head or brain) Intravascular stents, filters Shunt (spinal or intraventricular) Vascular access port or catheters Intrauterine device (IUD) Transdermal delivery system or other types of foil patches (e.g., Nitro, Nicotine, Birth control, etc.) that cannot be removed for MRI Shrapnel, buckshot, or bullets in body Tattooed eyeliner or eyebrows Body piercing(s) with metal that cannot be removed for MRI Metal fragments (eye, head, ear, skin) Internal pacing wires Aortic clips Metal or wire mesh implants Wire sutures or surgical staples Harrington rods (spine) Bone/joint pin, screw, nail, wire, plate in body Wig or toupee that cannot be removed for MRI Hair implants that involve staples or metal Hearing aid(s) that cannot be removed for MRI Dentures or retainers that cannot be removed for MRI


not yet accepting patients
Start Date
Completion Date
University of Southern California
Study Type
Expecting 240 study participants
Last Updated