AB-101 as Monotherapy and With Immunotherapy in Patients With Relapsed/Refractory B-Cell Non-Hodgkin Lymphoma

Open to people ages 18 years and up

• Confirmed diagnosis of indolent or aggressive NHL of B-cell origin.
• Patient must have progressed or demonstrated intolerance to at least two lines of FDA-approved therapies, one of which must have included anti-CD20 monoclonal antibody therapy. The following are permitted: Prior autologous hematopoietic stem cell transplantation, prior treatment with FDA-approved CAR-T therapy, and/or prior treatment with an investigational agent.
• Patient must have disease that allows for response assessment using the Lugano classification criteria.
• Ability to understand and sign the ICF.

• Active CNS lymphoma or CNS involvement unless there is a history of at least 3 months of sustained remission of treated disease.
• History of clinically significant structural cardiac disease.
• Cardiac ejection fraction of < 45% on echocardiogram or MUGA scan at screening assessment.
• Inadequate pulmonary function.
• History of a solid organ allograft, or an inflammatory or autoimmune disease likely to be exacerbated by IL-2.
• Ongoing uncontrolled systemic infections.
• Prior allogeneic stem cell transplant.
• Positive HIV PCR test
• Positive for Hepatitis B or Hepatitis C
• Females of childbearing potential must be willing and able to use appropriate contraception for duration of trial and for 6 months following final AB-101 dose. Males must be sterile or commit to using appropriate contraception until at least 4 months following lymphodepleting chemotherapy.
• Individuals who are pregnant or lactating are ineligible.