Summary

Eligibility
for people ages 18 years and up (full criteria)
Location
at Irvine, California and other locations
Dates
study started
completion around
Principal Investigator
by Deepa Jeyakumar

Description

Summary

This phase II trial studies how well inotuzumab ozogamicin and blinatumomab work in treating patients with CD22-positive B-lineage acute lymphoblastic leukemia that is newly diagnosed, has come back, or does not respond to treatment. Immunotherapy with monoclonal antibodies, such as inotuzumab ozogamicin and blinatumomab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.

Official Title

A Phase II Study of Inotuzumab Ozogamicin Followed by Blinatumomab for Ph-Negative CD22-Positive B-Lineage Acute Lymphoblastic Leukemia in Newly Diagnosed Older Adults or Adults With Relapsed or Refractory Disease

Details

Keywords

B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative, Recurrent B Acute Lymphoblastic Leukemia, Refractory B Acute Lymphoblastic Leukemia, Leukemia, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Lymphoid Leukemia, Philadelphia Chromosome, Immunological Antineoplastic Agents, Inotuzumab Ozogamicin, Blinatumomab, Antibodies, Immunoglobulins, Monoclonal Antibodies, Bispecific Antibodies, Muromonab-CD3, inotuzumab ozogamicin, blinatumomab

Eligibility

Locations

  • UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care accepting new patients
    Irvine California 92612 United States
  • UC Irvine Health/Chao Family Comprehensive Cancer Center accepting new patients
    Orange California 92868 United States

Lead Scientist at UC Irvine

  • Deepa Jeyakumar
    Associate Clinical Professor, Medicine, School of Medicine. Authored (or co-authored) 34 research publications

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
National Cancer Institute (NCI)
ID
NCT03739814
Phase
Phase 2 research study
Study Type
Interventional
Participants
Expecting 64 study participants
Last Updated