for people ages 50-70 (full criteria)
Healthy Volunteers
healthy people welcome
at Los Angeles, California
study started
estimated completion



In the current study, we will examine how daily paced breathing affects plasma amyloid beta levels and the rate of learning in older adults. Healthy adults aged 50-70 who meet all eligibility criteria will be invited to this study. Participants will be randomly assigned to one of the two conditions: 1) Daily memory and attention training followed by a paced breathing protocol designed to increase relaxation or 2) Daily memory and attention training followed by a paced breathing protocol to increase alertness. Participants will be asked to complete pre and post intervention cognitive testing online, engage in 10 weeks of daily brain training (starting Week 2) and 9 weeks of paced breathing (starting Week 3) at home and to come in for lab visits to provide blood and urine samples on Weeks 2, 7 and 12 to allow for assessment of amyloid beta levels.


Aging, Alzheimer Disease, Age-related Cognitive Decline, Cognitive Dysfunction, Brain training, Paced breathing, Brain training and paced breathing to stimulate alertness, Brain training and paced breathing to relax


You can join if…

Open to people ages 50-70

  • speak English fluently
  • between the age of 50-70
  • healthy adult who weighs at least 110 pounds
  • non-pregnant and non-menstruating (for at least the past year)
  • normal or corrected-to-normal vision and hearing
  • have a home computer with a physical keyboard and have access to reliable internet
  • have an email account that you check regularly
  • have a phone that receives text messages
  • willing to provide a blood sample and a urine sample at all lab visits
  • willing to devote up to 60 minutes daily to the study for 12 weeks (in addition to three lab visits)

You CAN'T join if...

  • currently practicing any relaxation, biofeedback, or breathing technique (e.g., meditation) for more than an hour a week
  • regularly played Lumosity games in the past 6 months
  • participated in heart rate biofeedback studies in the Emotion & Cognition Lab or other labs


  • University of Southern California
    Los Angeles California 90089 United States


not yet accepting patients
Start Date
Completion Date
University of Southern California
Study Type
Expecting 48 study participants
Last Updated