Summary

Eligibility
for people ages 18 years and up (full criteria)
Location
at Orange, California and other locations
Dates
study started
estimated completion
Principal Investigator
by Ritesh Parajuli, MD

Description

Summary

This study is being done to find out if zanidatamab when given with evorpacept (ALX148) is safe and can treat patients with advanced (locally advanced [inoperable] and/or metastatic) human epidermal growth factor receptor 2 (HER2)-expressing cancer.

Official Title

A Phase 1b/2, 2-part Open-label Study to Assess the Safety and Antitumor Activity of Zanidatamab in Combination With ALX148 in Advanced HER2-expressing Cancer

Details

Part 1 of the study will first evaluate the safety and tolerability and establish the recommended doses (RDs) of zanidatamab in combination with evorpacept (ALX148). Part 2 of the study will evaluate the anti-tumor activity of the combination of zanidatamab plus evorpacept (ALX148) at the RD levels in indication-specific expansion cohorts.

Keywords

HER2-expressing Cancers, Zanidatamab, Evorpacept, Zanidatamab plus evorpacept (ALX148)

Eligibility

You can join if…

Open to people ages 18 years and up

  • Locally advanced (inoperable) and/or metastatic HER2-expressing cancer based on local or central laboratory test results as follows:
  • Parts 1 and 2: HER2-positive breast cancer as defined per American Society of Clinical Oncology (ASCO)/ College of American Pathologists (CAP) guidelines
  • Parts 1 and 2: HER2-low breast cancer (defined as immunohistochemistry [IHC] 1+ or IHC 2+; AND is not HER2-positive per the ASCO/CAP guidelines)
  • Part 2: HER2-positive gastroesophageal adenocarcinoma as defined per the ASCO/CAP gastric cancer-specific guidelines; other HER2-overexpressing non-breast cancers (defined as IHC 3+; or IHC 2+ and in situ hybridization [ISH]+) per the ASCO/CAP guidelines for breast cancer
  • Progression after or during the most recent systemic regimen of treatment for advanced cancer. For both Part 1 and Part 2, prior therapies must have included approved agents known to confer clinical benefit.
  • Subjects with HER2-positive breast cancer who did not receive trastuzumab or pertuzumab due to medical contraindications will not be eligible for this study
  • Subjects with HER2-low breast cancer who have received prior HER2-targeted therapy will not be eligible for this study
  • Measurable disease per Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST 1.1)
  • Willingness to undergo a new biopsy to provide a tumor tissue for central laboratory testing of HER2 protein expression and gene amplification by IHC and ISH assays, respectively
  • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
  • Adequate organ functions
  • Adequate cardiac left ventricular function, as defined by a left ventricular ejection fraction (LVEF) ≥ 50% as determined by either echocardiogram or multiple gated acquisition scan (MUGA) obtained within 4 weeks prior to first dose of study treatment

You CAN'T join if...

  • Previous allogeneic stem cell transplant
  • Prior treatment with any anti-CD47 or anti-signal regulatory protein alpha (SIRPα) agent
  • Prior or concurrent invasive malignancy whose natural history or treatment has, in the opinion of the investigator or medical monitor, the potential to interfere with the safety or efficacy assessment of the investigational regimen
  • Received systemic anticancer therapy within 4 weeks of starting study treatment (6 weeks for mitomycin C or nitrosoureas). Received radiotherapy within 2 weeks of the first dose of zanidatamab/evorpacept (ALX148)
  • Untreated brain metastases, symptomatic brain metastases, or radiation treatment for brain metastases within 4 weeks of start of study treatment
  • Known leptomeningeal disease
  • Active hepatitis
  • Infection with human immunodeficiency virus (HIV)-1 or HIV-2. (Exception: Subjects with well controlled HIV [e.g., CD4 > 350/mm3 and undetectable viral load] are eligible.)
  • QTc Fridericia (QTcF) > 470 ms
  • History of myocardial infarction or unstable angina within 6 months prior to enrollment, troponin levels consistent with myocardial infarction, or clinically significant cardiac disease, such as ventricular arrhythmia requiring therapy, uncontrolled hypertension, or any history of symptomatic congestive heart failure
  • Acute or chronic uncontrolled pancreatitis or Child-Pugh Class C liver disease

Locations

  • UC Irvine Health - Chao Family Comprehensive Cancer Center accepting new patients
    Orange California 92868 United States
  • Pacific Center Medical Center, Inc. accepting new patients
    Anaheim California 92801 United States
  • UCLA Department of Medicine Hematology/Oncology accepting new patients
    Los Angeles California 90095 United States

Lead Scientist at UC Irvine

  • Ritesh Parajuli, MD
    Associate Clinical Professor, Medicine, School of Medicine. Authored (or co-authored) 12 research publications

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Zymeworks Inc.
ID
NCT05027139
Phase
Phase 1/2 HER2 Research Study
Study Type
Interventional
Participants
Expecting 93 study participants
Last Updated