for people ages 18 years and up (full criteria)
at Orange, California and other locations
study started
completion around



Pain is a symptom that drives hospital admissions, and pain management is required by most patients during their hospital stay. Further, the use of medications such as opioids can lead to upward-spiraling doses, especially among chronic pain patients whose resource utilization rates are high. Many initiatives aim to reduce the costs of these "high-resource utilizing" patients. One exciting aspect of improving the management of pain is that this may help prevent patients from ever becoming high-cost in the first place. The purpose of this study is to examine the impacts of an early and sustained intervention pathway, in comparison to the current standard of care, for the treatment of pain in opioid tolerant patients. It is hypothesized that patients randomized to the intervention pathway, in comparison to the control, will lead to decreased costs of care, a reduction in opioid usage within 3 and 6 months, and decrease in hospital readmission rates.

Official Title

Pain Management Options for Opioid Tolerant Patients: a Randomized Controlled Trial


Pain, Acute Pain, Postoperative Pain, patient readmission, pain relief units, pain centers, multidisciplinary pain clinics, multidisciplinary pain centers, pain clinics, hospital readmission, emergencies, emergency medicine, critical care, emergency treatment, opioid, acute pain service, New Clinical Pathway


You can join if…

Open to people ages 18 years and up

  • Adult patients (18 years and older)
  • Known opioid tolerant (as determined per FDA criteria)
  • Agree to sign the informed consent and HIPAA forms

You CAN'T join if...

  • Patients under the age of 18 years
  • No known opioid tolerance
  • Do not agree to sign the informed consent and HIPAA forms


  • University of California, Irvine Medical Center
    Orange California 92868 United States
  • Duke University Medical Center
    Durham North Carolina 27710 United States


currently not accepting new patients, but might later
Start Date
Completion Date
Duke University
Study Type
Expecting 1200 study participants
Last Updated