for people ages 18 years and up (full criteria)
at Orange, California and other locations
study started
completion around



This study is a substudy being conducted under one pembrolizumab umbrella master study KEYMAKER-U04. The substudy will consist of 2 parts. Part 1 will evaluate the efficacy and safety of coformulated favezelimab/pembrolizumab plus EV and coformulated vibostolimab/pembrolizumab plus EV relative to pembrolizumab plus EV. There will be no comparison of coformulated favezelimab/pembrolizumab plus EV versus coformulated vibostolimab/pembrolizumab plus EV. If ORR and/or DRR are substantially better on coformulated favezelimab/pembrolizumab plus EV and/or coformulated vibostolimab/pembrolizumab plus EV compared with pembrolizumab plus EV, after evaluation of the totality of data, the sponsor might consider Part 2 (expansion) to further characterize the efficacy and safety of the treatment arms under study.

Official Title

A Phase 1/2 Randomized, Umbrella Study to Evaluate the Safety and Efficacy of Pembrolizumab Plus Enfortumab Vedotin (EV) in Combination With Investigational Agents Versus Pembrolizumab Plus EV, as First-Line Treatment for Participants With Advanced Urothelial Carcinoma (KEYMAKER-U04): Substudy 04B


The master study for this substudy is MK-3475-U04/KEYMAKER-U04. The master study will not be screening any participants and will not be registered.


Metastatic Urothelial Carcinoma, Urothelial Neoplasms, Carcinoma, Transitional Cell Carcinoma, Pembrolizumab, Coformulated favezelimab/pembrolizumab, Coformulated vibostolimab/pembrolizumab, Coformulated favezelimab/pembrolizumab plus EV, Coformulated vibostolimab/pembrolizumab plus EV, Pembrolizumab plus EV


You can join if…

Open to people ages 18 years and up

  • Must have histologically documented, locally advanced/metastatic urothelial carcinoma (la/mUC).
    • Participants with mixed histology are eligible provided the urothelial component is ≥50% (and <10% plasmacytoid component)
    • Participants whose tumors contain any neuroendocrine component are not eligible (variant histology to be confirmed locally)
  • Must not have received prior systemic therapy for la/mUC. The following therapies in earlier disease setting (eg, muscle-invasive urothelial carcinoma (MIUC)) are permitted:
    • Participants that received neoadjuvant or adjuvant chemotherapy are permitted.
    • Participants who received anti- programmed cell death 1 protein (PD-1) or programmed cell death ligand 1 (PD-L1) therapy for an earlier disease stage (eg, NMIBC, MIUC) with progression/recurrence >12 months from completion of therapy are permitted.
  • Must provide an archival tumor tissue sample or newly obtained core or excisional biopsy of a tumor lesion demonstrating UC, not previously irradiated, and adequate for biomarker evaluation. A newly obtained biopsy is strongly preferred, but not required if archival tissue is evaluable.
  • Any AEs due to previous anticancer therapies must have recovered to ≤Grade 1 or baseline. Endocrine-related AEs adequately treated with hormone replacement or with <Grade 2 neuropathy are eligible.

You CAN'T join if...

  • Has a known additional malignancy, except if the participant has undergone potentially curative therapy with no evidence of that disease recurrence for at least 3 years since initiation of that therapy.
  • Central nervous system (CNS) metastases are permitted on-study if all of the following are true: a) CNS metastases have been clinically stable for at least 4 weeks prior to screening and baseline scans show no evidence of new or enlarged metastasis; b) the participant is on a stable dose of ≤10 mg/day of prednisone or equivalent for at least 2 weeks (if requiring steroid treatment); c) participant does not have leptomeningeal disease.
  • Has received a live or live-attenuated vaccine within 30 days prior to the first dose of study intervention.
  • Has received an investigational agent or has used an investigational device within 4 weeks prior to study intervention administration.
  • Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior the first dose of study intervention. Inhaled or topical steroids are permitted in the absence of active autoimmune disease. Physiologic replacement doses of corticosteroids are permitted for participants with adrenal insufficiency.
  • Has active keratitis or corneal ulcerations. Superficial punctate keratitis is allowed if the disorder is being adequately treated in the opinion of the investigator.
  • Has an active autoimmune disease that has required systemic treatment in past 2 years except replacement therapy.
  • Has a history of uncontrolled diabetes.
  • Has a history of (noninfectious) pneumonitis that required steroids or has current pneumonitis
  • Has an active infection (viral, bacterial, or fungal) requiring systemic therapy.
  • Has a known history of human immunodeficiency virus (HIV) infection.
  • Has hepatitis B or hepatitis C virus infection.
  • Has had major surgery within 4 weeks prior to first dose of study intervention.
  • Has had an allogenic tissue/solid organ transplant


  • University of California, Irvine (UCI) Health - UC Irvine Medical Center ( Site 3045)
    Orange California 92868 United States
  • Moores Cancer Center ( Site 3028)
    La Jolla California 92093 United States


in progress, not accepting new patients
Start Date
Completion Date
Merck Sharp & Dohme LLC
Merck Clinical Trials Information Plain Language Summary
Phase 1/2 research study
Study Type
Expecting 390 study participants
Last Updated