for people ages 40 years and up (full criteria)
at Orange, California and other locations
study started
completion around



This study will investigate the effect of tirzepatide on the reduction of morbidity and mortality in adults living with obesity and provide additional evidence for the potential clinical benefits of tirzepatide in this population.

Official Title

A Phase 3, Randomized, Double-blind, Placebo-Controlled Study to Investigate the Effect of Tirzepatide on the Reduction of Morbidity and Mortality in Adults With Obesity


Obesity, Overweight, Tirzepatide


You can join if…

Open to people ages 40 years and up

  • Have a body mass index (BMI) ≥27.0 kilogram/square meter (kg/m ²)
  • Are either
    • individuals ≥40 years of age with established cardiovascular disease (CVD).
      • CVD is defined as meeting at least one of the following:

        - Coronary artery disease - Cerebrovascular disease

      • Peripheral arterial disease OR
      • individuals without established CVD but have the presence of cardiovascular (CV) risk factors (primary prevention)
      • women 55-69 years of age or men 50-64 years of age with at least 3 risk factors like tobacco use, dyslipidemia, hypertension at screening, or

        - women ≥70 years of age or men, ≥65 years of age with at least 2 risk factors at screening.

You CAN'T join if...

  • Have type 1 diabetes (T1D) or (T2D), history of ketoacidosis, or hyperosmolar state/coma
  • Have laboratory evidence diagnostic of diabetes mellitus at screening of HbA1c ≥6.5% (≥48 millimole/mole (mmol/mol) or fasting glucose (FG) ≥126 milligram/deciliter (≥7.0 millimole/liter (mmol/L).
  • Any one of the following CV conditions within 90 days prior to screening
    • MI
    • acute coronary syndrome
    • stroke
    • coronary or peripheral arterial revascularization procedure, which may also include carotid artery revascularization, or
    • acute decompensated heart failure
  • Have a known clinically significant gastric emptying abnormality such as severe gastroparesis or gastric outlet obstruction or have undergone or currently planning any gastric bypass (metabolic) surgery or restrictive bariatric surgery. Note: Liposuction or abdominoplasty are not considered as gastric bypass procedures.
  • Have a history of chronic or acute pancreatitis
  • Have a family or personal history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2.
  • Have acute or chronic hepatitis, or clinical signs or symptoms of any other liver disease, or have elevated liver enzyme measurements, determined by the central laboratory at screening
  • Have a presence or history of malignant neoplasms within the past 5 years prior to screening.


  • University of California Irvine Medical Center
    Orange California 92868 United States
  • Velocity Clinical Research, Santa Ana
    Santa Ana California 92704 United States
  • HB Clinical Trials - Fountain Valley
    Fountain Valley California 92708 United States
  • Diabetes Associates Medical Group
    Orange California 92868 United States
  • Smart Cures Clinical Research
    Anaheim California 92806 United States
  • Long Beach Clinical Trials
    Long Beach California 90806 United States
  • Infinity Clinical Research - Norco
    Norco California 92860 United States
  • Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
    Torrance California 90502 United States
  • Artemis Institute for Clinical Research
    Riverside California 92503 United States
  • Valiance Clinical Research
    S. Gate California 90280 United States


in progress, not accepting new patients
Start Date
Completion Date
Eli Lilly and Company
A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity (SURMOUNT-MMO)
Phase 3 Obesity Research Study
Study Type
About 15374 people participating
Last Updated