for people ages 18-50 (full criteria)
healthy people welcome
at Irvine, California and other locations
study started
estimated completion
Beckman Laser Institute and Medical Center



The purpose of this is that the researcher can use low power Near Infrared laser treatment non-painful and non-damaging dose to changes the skin properties.The researcher can prove that signaling and a significant increase in the number of skin cells in skin tissue exposed to the laser can improve the human skin immune system to help improve human body response to vaccines.


The researcher can use low power laser light one-minute exposures delivered to the skin at non-painful and non-damaging dose. The resulted in significant immunologic changes in the skin that included up-regulation of specific skin tissue and skin genes and the activation and mobilization of specific skin cells.

In the first part of the study, the researcher will make a determination of the laser irradiance that will be tolerated. The highest irradiance the subject tolerates for 1 minute will be identified as that subject's maximum tolerable irradiance. After all subjects are tested, researcher will select the highest irradiance that was tolerated and use this in the second phase of the study.

Approximately 24 hours after the first test exposures, each subject will receive a one minute laser treatment at the maximum tolerable irradiance. Four hours later, two skin biopsies will be collected from laser treated site a untreated.

One tissue sample will be test at UC Irvine Dept. of Dermatopathology to evaluate microscopic skin changes, one skin sample will be delivered to Massachusetts General Hospital to evaluate RNA and protein expression.


Vaccine Response Impaired low power laser


You can join if…

Open to people ages 18-50

  • Adult men and women with skin type 1 and 2
  • Not pregnant

You CAN'T join if...

  • Use of systemic steroids, topical steroids, tanning solutions and anticoagulant
  • History of HIV, mentally incompetent, prisoner, alcohol or drug impairment
  • Abnormal photosensitivity


  • Beckman Laser Institute accepting new patients
    Irvine California 92612 United States
  • Vaccine and Immunotherapy Center Massachusetts General Hospital not yet accepting patients
    Charlestown Massachusetts 02129 United States

Lead Scientist


accepting new patients
Start Date
Completion Date
University of California, Irvine
Phase 1
Study Type
Last Updated