Parkinson's Disease clinical trials at UC Irvine

8 in progress, 1 open to eligible people

Showing trials for

  • Parkinson's and Zoledronic Acid

    open to eligible people ages 60 years and up

    This home-based study is a randomized (1:1) placebo-controlled trial of a single infusion of zoledronic acid-5 mg (ZA) for the prevention of fractures in men and women aged 60 years and older with Parkinson's disease and parkinsonism with at least 2 years of follow-up. A total of 3500 participants will be enrolled and randomized in the United States. Participants, follow-up outcome assessors, and study investigators will be blinded to assigned study treatment. This trial is funded by the National Institute of Aging.

    Irvine, California and other locations

  • GDNF Gene Therapy for Parkinson's Disease

    Sorry, in progress, not accepting new patients

    The objective of this Phase 1b investigation is to evaluate the safety and potential clinical effect of AAV2-GDNF delivered to the putamen in subjects with either a recent or a long-standing diagnosis of PD.

    Irvine, California and other locations

  • Light Therapy for PD - Dose Selection

    Sorry, in progress, not accepting new patients

    This study aims to determine the most effective dose of light therapy to improve sleep in people with Parkinson's Disease. Four groups of participants will receive bright-white or dim-red light therapy at different times throughout the day.

    Irvine, California and other locations

  • ANPD001 in Parkinson Disease

    Sorry, accepting new patients by invitation only

    This clinical trial is designed to test the safety and tolerability of injecting ANPD001 cells that will mature into dopamine-producing cells into the brain of participants with Parkinson Disease. All participants will have ANPD001 cells manufactured from their own previously collected cells.

    Orange, California and other locations

  • VY-AADC02 for Parkinson's Disease With Motor Fluctuations (RESTORE-1)

    Sorry, in progress, not accepting new patients

    The objective of this study is to assess the safety of VY-AADC02 in participants with Parkinson's disease (PD) with motor fluctuations.

    Irvine, California and other locations

  • Continued Evaluation of Patients With Parkinson's Disease Who Previously Received BRT-DA01

    Sorry, accepting new patients by invitation only

    This is a multicenter study to evaluate the safety and clinical outcomes of BRT-DA01 in subjects with PD who previously received BRT-DA01 in the Phase 1 Study MSK-DA01-101.No investigational therapy will be administered in this study.

    Orange, California and other locations

  • Noninterventional Study Evaluating Parkinson's Disease Diary Use

    Sorry, in progress, not accepting new patients

    This study aims to evaluate the impact of the frequency of assessments on the variability over time, reliability, and compliance for the Parkinson's disease (PD) diary in patients with PD in whom medications do not provide adequate control of symptoms.

    Orange, California and other locations

  • Pre-Gene Therapy Study in Parkinson's Disease and Multiple System Atrophy

    Sorry, in progress, not accepting new patients

    The objective of this study is to describe disease progression in study participants diagnosed with early Parkinson's Disease or Multiple System Atrophy - Parkinsonian Type up to 18 months as delineated by clinical and biochemical parameters.

    Irvine, California and other locations

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