This study is in progress, not accepting new patients

INSPIRE Trial for Skin and Soft Tissue Infections

a study on Skin and Soft Tissue (SST) Infection

Summary

Eligibility
for people ages 18 years and up (full criteria)
Location
at Riverside, California and other locations
Dates
study started
completion around
Principal Investigator
by Susan Huang, MD, MPH

Description

Summary

The INSPIRE Skin and Soft Tissue Infection trial is a cluster-randomized controlled trial of HCA Healthcare hospitals comparing routine empiric antibiotic stewardship practices with real-time, precision medicine computerized physician order entry (CPOE) smart prompts providing the probability that a non-critically ill adult admitted with skin and soft tissue infection is infected with a resistant pathogen.

Note: enrolled "subjects" represent 102 individual HCA Healthcare hospitals that have been randomized into 92 clusters. Hospitals were grouped into the same randomization cluster if they shared campuses or antibiotic stewardship staff.

Official Title

The INSPIRE-ASP Trial (INtelligent Stewardship Prompts to Improve Real-Time Empiric Antibiotic Selection for Patients) for Skin and Soft Tissue (SST) Infections

Keywords

Skin and Soft Tissue (SST) Infection, SST, CPOE, Empiric Therapy, Infections, Communicable Diseases, Arm 1: Routine Care, Arm 2: INSPIRE Stewardship Bundle for Skin and Soft Tissue Infection, INSPIRE Stewardship Bundle

Eligibility

For people ages 18 years and up

Facility Inclusion Criteria:

  1. HCA Healthcare hospitals admitting adults for skin and soft tissue infection
  2. Facility use of MEDITECH as their electronic health record system

Facility Exclusion Criteria:

  • Note: unit of randomization is the hospital, however the computerized physician order entry (CPOE) alert intervention will calculate risk estimates for adults age >=18 admitted to non-intensive care unit wards and who are ordered to receive extended-spectrum antibiotics for skin and soft tissue infection.

Locations

  • Riverside Community hospital
    Riverside California 92501 United States
  • West Hills Hospital & Medical Center
    West Hills California 91307 United States

Lead Scientist at UC Irvine

  • Susan Huang, MD, MPH
    Professor, Medicine, School of Medicine. Authored (or co-authored) 199 research publications

Details

Status
in progress, not accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
Harvard Pilgrim Health Care
ID
NCT05423756
Study Type
Interventional
Participants
About 102 people participating
Last Updated