for people ages 18 years and up (full criteria)
at Riverside, California and other locations
study started
estimated completion
Principal Investigator
by Susan Huang, MD, MPH



The INSPIRE Skin and Soft Tissue Infection trial is a cluster-randomized controlled trial of HCA Healthcare hospitals comparing routine empiric antibiotic stewardship practices with real-time, precision medicine computerized physician order entry (CPOE) smart prompts providing the probability that a non-critically ill adult admitted with skin and soft tissue infection is infected with a resistant pathogen. Note: enrolled "subjects" represent 102 individual HCA Healthcare hospitals that have been randomized into 92 clusters. Hospitals were grouped into the same randomization cluster if they shared campuses or antibiotic stewardship staff.

Official Title

The INSPIRE-ASP Trial (INtelligent Stewardship Prompts to Improve Real-Time Empiric Antibiotic Selection for Patients) for Skin and Soft Tissue (SST) Infections


Skin and Soft Tissue (SST) Infection, SST, CPOE, Empiric Therapy, Infections, Communicable Diseases, Arm 1: Routine Care, Arm 2: INSPIRE CPOE Smart Prompt for Skin and Soft Tissue Infection, INSPIRE CPOE Smart Prompt


For people ages 18 years and up

Facility Inclusion Criteria:

  1. HCA Healthcare hospitals admitting adults for skin and soft tissue infection
  2. Facility use of MEDITECH as their electronic health record system

Facility Exclusion Criteria:


Note: unit of randomization is the hospital, however the computerized physician order entry (CPOE) alert intervention will calculate risk estimates for adults age >=18 admitted to non-intensive care unit wards and who are ordered to receive extended-spectrum antibiotics for skin and soft tissue infection.


  • Riverside Community hospital accepting new patients
    Riverside California 92501 United States
  • West Hills Hospital & Medical Center accepting new patients
    West Hills California 91307 United States

Lead Scientist at UC Irvine

  • Susan Huang, MD, MPH
    Professor, Medicine, School of Medicine. Authored (or co-authored) 187 research publications


accepting new patients
Start Date
Completion Date
Harvard Pilgrim Health Care
Study Type
Expecting 102 study participants
Last Updated