for people ages 18 months to 7 years (full criteria)
at Santa Ana, California and other locations
study started
completion around



This study involves sample collection to identify biomarkers relating to Autism Spectrum Disorder(ASD) in the saliva of children who are between the ages of 18 months to 6 years and 11 months. Participants will at each timepoint have a non-invasive saliva swab collected and complete a brief demographic and medical history questionnaire as well. Children in the pediatric/provider setting who will receive a referral for an ASD diagnosis because they were determined to have a suspicion of developing ASD will be enrolled in the study. Children will also be enrolled in the specialist evaluation setting where they will receive a DSM-5 diagnosis. A subset of both enrollment cohorts will also be followed up with at a third time point in which their diagnosis will be confirmed, and information about any ongoing treatment will be gathered.

Official Title

Validation of a Salivary miRNA Diagnostic Test for Autism Spectrum Disorder


Autism Spectrum Disorder, Developmental Delay, ASD, Saliva, Biomarkers, Autistic Disorder, Pervasive Child Development Disorders, Salivary Collection, Adaptive Assessment, Autism Assessment, Intellectual Development Assessment, Autism Spectrum Disorder (ASD)


You can join if…

Open to people ages 18 months to 7 years

  • 18 through 83 months old
  • The study will include children "at risk" for ASD as defined by meeting one or more of the following criteria:
    • flagged positive on a developmental screening tool (see below for assessment cut off scores)
    • the child has a biological sibling with ASD
    • Significant provider concern based on parent report noted in the child's medical chart at the time of the appointment.
    • Significant parental concern

You CAN'T join if...

  • Feeding tube dependence
  • Active periodontal disease
  • Confounding neurological condition (i.e. cerebral palsy, epilepsy)
  • Sensory impairments (i.e. blindness or deafness)
  • Acute illnesses (i.e. upper respiratory infection)
  • Currently on antibiotics
  • Had taken antibiotics within the previous 30 days
  • Wards of the state


  • University of California - Irvine accepting new patients
    Santa Ana California 92705 United States
  • Seattle Children's Hospital accepting new patients
    Seattle Washington 98105 United States


accepting new patients
Start Date
Completion Date
Quadrant Biosciences Inc.
Study Type
Expecting 6604 study participants
Last Updated