for people ages 18 years and up (full criteria)
at Orange, California and other locations
study started
estimated completion
Principal Investigator
by Susan O'Brien



This study evaluates the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). CLL and SLL are types of blood cancer that begin in cells of the immune system. CLL/SLL and the medications used to treat these conditions may change the way vaccines work in a patient's body. The purpose of this study is to find out if patients with CLL/SLL make antibodies, or have an immune response, to the SARS-CoV-2 vaccines. Information gained from this study may help researchers better understand how effective the vaccines work in preventing COVID-19 (coronavirus disease 2019) in patients with CLL and SLL.

Official Title

Multicenter Evaluation of SARS-CoV-2 Vaccines in Patients With CLL/SLL


OUTLINE: For patients who have not been vaccinated at the time of enrollment, they will undergo collection of blood samples prior to the first vaccine dose, just before the second vaccine dose, and then at 1, 6, and 12 months after the second vaccine dose. Patients' medical records are also reviewed. For patients enrolled after vaccination, they will undergo collection of blood samples at 1-4, 6, and 12 months after completing the vaccination series. Patients who receive booster dose also undergo collection of blood samples at 1, 6, and 12 months post final booster dose. After completion of study, patients are followed up every 6 months for 2 years.


Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Lymphoma, Leukemia, Leukemia, Lymphoid, Leukemia, Lymphocytic, Chronic, B-Cell, Biospecimen Collection, Electronic Health Record Review


You can join if…

Open to people ages 18 years and up

You CAN'T join if...

  • Any evidence of prior SARS-CoV-2/COVID19 infection


  • UC Irvine Health/Chao Family Comprehensive Cancer Center accepting new patients
    Orange California 92868 United States
  • City of Hope accepting new patients
    Duarte California 91010 United States

Lead Scientist at UC Irvine


accepting new patients
Start Date
Completion Date
University of Washington
Study Type
Expecting 500 study participants
Last Updated