High Blood Pressure clinical trials at UC Irvine

13 in progress, 6 open to eligible people

Showing trials for

  • Ralinepag to Improve Treatment Outcomes in PAH Patients

    open to eligible people ages 18 years and up

    Study ROR-PH-301, ADVANCE OUTCOMES, is designed to assess the efficacy and safety of ralinepag when added to pulmonary arterial hypertension (PAH) standard of care or PAH-specific background therapy in subjects with World Health Organization (WHO)…

    Orange, California and other locations

  • Acupuncture Therapy and Hypertension

    open to eligible people ages 40-75

    Acupuncture therapy will be provided to reduce blood pressure in hypertensive patients. The mild to moderate hypertensive patients will be either on or off hypertensive medications. The course last for 8 weeks and the frequency is once a week.

    Orange, California and other locations

  • Early Feasibility Study of "HyperQureTM RDN System", Laparoscopic Renal Denervation Therapy, in Patients With Resistant Hypertension

    open to eligible people ages 22-80

    HQ-HTN-G01 is a prospective, multicenter, single arm, open label, early feasibility study to evaluate initial safety and device design concept of "HyperQureTM RDN System", laparoscopic renal denervation therapy, in patients with resistant…

    Orange, California and other locations

  • Electro-Acupuncture on Blood Pressure

    open to eligible people ages 18-85

    Based on previous published research in animals and human, the investigators hypothesize that electroacupuncture (EA) will have a positive effect on hypertension.

    Irvine, California and other locations

  • Seralutinib in Adult Subjects With PAH (PROSERA)

    open to eligible people ages 18-75

    The primary objective of the study is to determine the effect of seralutinib on improving exercise capacity in subjects with WHO Group 1 PAH who are FC II or III. The secondary objective for this trial is to determine time to clinical worsening.

    Orange, California and other locations

  • Reducing Blood Pressure in Patients With High Cardiovascular Risk in the Safety-Net

    open to eligible people ages 35 years and up

    BP-REACH is a study of a team-based (pharmacist and health coach) program for lowering blood pressure for people with a prior stroke or heart attack in the Los Angeles Department of Health Services public healthcare system. The goal of this clinical …

    Downey, California and other locations

  • Dietary Sodium Intake and Blood Pressure in Living Kidney Donors

    Sorry, currently not accepting new patients, but might later

    This is a pilot study to determine the feasibility of the study design and examine the main outcome whether low dietary sodium intake is superior to high dietary sodium intake in controlling blood pressure to be within the normotensive range in…

    Orange, California

  • Sotatercept for PAH Treatment (MK-7962-004/A011-12)

    Sorry, in progress, not accepting new patients

    This study is being conducted to assess the long-term safety, tolerability, and efficacy of sotatercept (MK-7962, formerly called ACE-011) in participants with Pulmonary Arterial Hypertension (PAH). This open-label, long-term follow-up (LTFU) study…

    Orange, California and other locations

  • Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension

    Sorry, accepting new patients by invitation only

    Study ROR-PH-303, ADVANCE EXTENSION, is an open-label extension (OLE) study for participants with WHO Group 1 PAH who have participated in another Phase 2 or Phase 3 study of ralinepag.

    Orange, California and other locations

  • Sotatercept for the Treatment of Cpc-PH Due to HFpEF (MK-7962-007/A011-16)

    Sorry, in progress, not accepting new patients

    This is a Phase 2, double-blind, randomized, placebo-controlled study to evaluate the efficacy and safety of sotatercept versus placebo in adults with Cpc-PH due to HFpEF. The objective of this study is to evaluate the efficacy, safety and…

    Orange, California and other locations

  • Skills-Based Educational Strategies for Reduction of Vascular Events in Orange County

    Sorry, in progress, not accepting new patients

    The Skills-Based Educational strategies for Reduction of Vascular Events in Orange County, CA (SERVE OC) study aims to evaluate the efficacy of a culturally tailored, skills-based, cardiovascular health (CVH) intervention amongst a cohort of Latinx…

    Irvine, California

  • Sotatercept in Newly Diagnosed Intermediate- and High-Risk PAH Participants (MK-7962-005/A011-13)

    Sorry, in progress, not accepting new patients

    The objective of this study is to evaluate the effects of sotatercept (MK-7962, formerly called ACE-011) treatment (plus background pulmonary arterial hypertension (PAH) therapy) versus placebo (plus background PAH therapy) on time to clinical…

    Orange, California and other locations

  • Validation of SEARCH, a Novel Hierarchical Algorithm to Define Long-term Outcomes After Pulmonary Embolism

    Sorry, accepting new patients by invitation only

    Potential outcomes after PE occur on a spectrum: complete recovery, exercise intolerance from deconditioning/anxiety, dyspnea from concomitant cardiopulmonary conditions, dyspnea from residual pulmonary vascular occlusion, chronic thromboembolic…

    Irvine, California and other locations

Our lead scientists for High Blood Pressure research studies include .

Last updated: