for people ages 15-80 (full criteria)
at Orange, California and other locations
study started
estimated completion
Principal Investigator
by Sandra Sunhee Park



The reason for this study is to see if the study drug mirikizumab is safe and effective in participants with moderately to severely active Crohn's disease.

Official Title

A Phase 3, Multicenter, Randomized, Double-Blind, Placebo- and Active- Controlled, Treat-Through Study to Evaluate the Efficacy and Safety of Mirikizumab in Patients With Moderately to Severely Active Crohn's Disease


Crohn's Disease Crohn Disease Mirikizumab Ustekinumab


You can join if…

Open to people ages 15-80

  • Diagnosis of CD for at least 3 months prior to baseline
  • Confirmed diagnosis of moderate to severe CD as assessed by SF, AP score, and SES-CD
  • Demonstrated intolerance, loss of response or inadequate response to conventional or to biologic therapy for CD
  • If female, subject must meet the contraception recommendations

You CAN'T join if...

  • Have a current diagnosis of ulcerative colitis, inflammatory bowel disease-unclassified (IBD-U) (formerly known as indeterminate colitis) or short bowel syndrome
  • Currently have or are suspected to have an abscess. Recent cutaneous and perianal abscesses are not exclusionary if drained, adequately treated and resolved at least 3 weeks prior to baseline or 8 weeks prior to baseline for intra-abdominal abscesses, provided that there is no anticipated need for any further surgery
  • Have a stoma, ileoanal pouch or ostomy
  • Have had a bowel resection within 6 months, or any kind of intra-abdominal or extra abdominal surgery within 3 months of baseline
  • Have ever received any monoclonal antibodies binding IL-23


  • University of CA, Irvine accepting new patients
    Orange California 92868 United States
  • Wolverine Clinical Trials, LLC accepting new patients
    Santa Ana California 92705 United States
  • Newport Huntington Med Grp accepting new patients
    Huntington Beach California 92648 United States
  • Childrens Hospital of Orange County accepting new patients
    Orange California 92868 United States

Lead Scientist at UC Irvine


accepting new patients
Start Date
Completion Date
Eli Lilly and Company
A Study of Mirikizumab (LY3074828) in Participants With Crohn's Disease
Phase 3
Study Type
Last Updated