for people ages 18 years and up (full criteria)
at Irvine, California
study started
estimated completion
Angela G Fleischman, MD PhD



The purpose of this study is to determine whether MPN patient are able to adhere to a dietary intervention. Participants will be randomized to one of two healthy diets. Participants will receive in person dietician counseling and online curriculum. Adherence will be measured using online surveys and phone diet recalls. Changes in inflammatory markers in blood will also be measured at 5 time points during this 15 week study.


This is a 15 week study, including 10 weeks of active diet intervention. Each participant will receive one dietician counseling session at the beginning of the diet intervention period, two brief follow up dietician phone calls, and 10 diet education handouts delivered via email each week. The main objective of this protocol is to test whether MPN patients can adhere to a diet intervention. The investigators will measure adherence in both arms with patient reported diet recall every two weeks via internet surveys. As exploratory endpoints the investigators will measure changes in inflammatory markers, symptom burden, physical activity level, sleep, and gut microbiome in participants over the course of the study. If successful, the investigators plan to use this intervention in a larger trial to assess whether a diet intervention can effectively change symptom burden and inflammation in MPN patients.


Myeloproliferative Disorder Myeloproliferative Syndrome Myelofibrosis Polycythemia Vera Essential Thrombocythemia nutrition diet inflammation myeloproliferative neoplasm Polycythemia Myeloproliferative Disorders Thrombocytosis Thrombocythemia, Essential Neoplasms Nutrients USDA Diet Mediterranean Diet


You can join if…

Open to people ages 18 years and up

  • At least 18 years old
  • Diagnosis of Myeloproliferative Neoplasm (MPN) including Essential Thrombocythemia (ET), Polycythemia Vera (PV), or Myelofibrosis (MF)
  • Any type of previous therapy is allowed
  • ECOG performance status ≤2
  • Life expectancy of greater than 20 weeks
  • Has an email address and can access the internet
  • Able to read and understand English

You CAN'T join if...

  • Children


  • University of California, Irvine accepting new patients
    Irvine California 92617 United States

Lead Scientist


accepting new patients
Start Date
Completion Date
University of California, Irvine
website with more information on the diet and enrollment information
Study Type
Last Updated