for females ages 18-40 (full criteria)
Healthy Volunteers
healthy people welcome
at Orange, California
study started
estimated completion
Principal Investigator
by Karen L Lindsay



This study seeks to understand how a mother's emotional state in pregnancy influences her biological response to food intake.

Official Title

Prenatal Emotion-Diet Interactions and the Metabolic Response


The purpose of this research study is to understand how a mother's emotional state in pregnancy influences her biological response to food intake. Natural variation in emotional and mental state is frequently experienced in daily life, including during pregnancy. While the investigators understand that a healthy diet is important in pregnancy for maintaining blood sugar levels and other metabolic factors within normal ranges for optimal development of the baby, less consideration is given to the health effects of a mother's mental state during pregnancy. It may even be possible that, regardless of what a woman eats or drinks, the way her body responds to food may differ according to her emotional or mental state. This research is particularly interested in understanding how the combination of maternal emotional state and diet influence metabolism in pregnancy. Thus, the aim of this study is to test whether and how an individual's emotional response to a mental challenge of varying complexity during pregnancy modifies the body's metabolic response to a standard breakfast.


Pregnancy Related Stress, Psychological Glucose Intolerance During Pregnancy pregnancy metabolism stress emotional state diet glycemic response Glucose Intolerance Trier Social Stress Test Psychosocial challenge task


You can join if…

Open to females ages 18-40

  • Age 18-40 years
  • Hispanic ethnicity
  • English and/or Spanish speaking
  • Multiparous
  • 28-30 week's gestation
  • Pre-pregnancy BMI 25.0-34.9 kg/m2
  • Singleton, intrauterine pregnancy
  • Non-smoker
  • Non-diabetic and negative result on routine prenatal glucose challenge test (GCT)

You CAN'T join if...

  • BMI <25.0 or ≥35.0 kg/m2
  • >30 week's gestation
  • multiple pregnancy
  • nulliparous
  • present/prior obstetric risk conditions (hypertension, preeclampsia, infections, placental abnormalities)
  • current smoker
  • current psychiatric disorders or undergoing treatment/taking psychiatric medications
  • Use of systemic/frequent corticosteroids or thyroid meds
  • Diabetic or presence of other metabolic or neuroendocrine disorders


  • UCI Medical Center, University of California, Irvine accepting new patients
    Orange California 92868 United States

Lead Scientist at UC Irvine

  • Karen L Lindsay
    Assistant Professor, Pediatrics. Authored (or co-authored) 33 research publications.


accepting new patients
Start Date
Completion Date
University of California, Irvine
Study Type
Last Updated