Summary

for people ages 18-75 (full criteria)
study started
estimated completion
Connie M. Rhee

Description

Summary

Hypothyroidism, defined by elevated thyrotropin (TSH) levels, is a common endocrine complication of chronic kidney disease that has been associated with impaired quality of life and cardiovascular complications. While levothyroxine is one of the most frequently prescribed medications in chronic kidney disease patients, little is known about its efficacy and safety in this population. This study will investigate 1) whether levothyroxine adequately lowers thyrotropin (TSH) levels to therapeutic target ranges, and 2) if thyroid hormone replacement improves quality of life and cardiovascular markers, without leading to wasting in dialysis patients.

Keywords

Thyroid DiseaseKidney Diseases, ChronicKidney DiseasesThyroid DiseasesChronic DiseaseRenal Insufficiency, ChronicHormonesLevothyroxine SodiumLevothyroxine

Eligibility

You can join if…

Open to people ages 18-75

  • Prevalent hemodialysis patients, elevated thyrotropin level, normal free thyroxine level.

You CAN'T join if...

  • Hyperthyroidism, active treatment with thyroid hormone replacement, prior thyroid malignancy, active pregnancy, active coronary ischemia or atrial fibrillation, osteoporosis, inability to provide consent without a proxy.

Lead Scientist

Details

Status
not yet accepting patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, Irvine
ID
NCT03191188
Study Type
Interventional
Last Updated