for females ages 21 years and up (full criteria)
Healthy Volunteers
healthy people welcome
at Irvine, California and other locations
study started
completion around



The ULTRA Registry is a nationwide observational arm of the ULTRA trial. Data from the ULTRA Registry will be used to evaluate the long-term safety and efficacy of laparoscopic RF ablation (Acessa).

The ULTRA Registry will recruit women age 21 or older who plan to undergo or have undergone laparoscopic RF ablation (Acessa) or myomectomy within the United States. Participants will be recruited through study materials distributed at clinical offices across the country where gynecologists are performing laparoscopic RF ablation (Acessa). Study participants will consent to participate in a 3 year prospective study conducted by UCSF but the fibroid procedure will be performed by the study participants' own gynecologist. We will evaluate changes in fibroid-related symptoms from pre-treatment values to 6, 12, 18, 24, 30, and 36 months after RFA (Acessa). We will determine long-term efficacy of RFA (Acessa) by evaluating the rate of re-treatment for symptomatic fibroids after the RFA (Acessa) procedure versus myomectomy. Participants will be asked for permission to review their medical records to assess surgical and pregnancy outcomes.

UC San Francisco will have oversight of all scientific and administrative aspects of the study. All study data will be stored securely in a HIPAA compliant, secure database monitored by the UC San Francisco Coordinating Center.


Uterine Fibroids, Fibroids, Radiofrequency ablation, Myomectomy, Leiomyoma, Myofibroma, Radiofrequency ablation of fibroids, Myomectomy of fibroids, Women undergoing radiofrequency ablation., Women undergoing myomectomy


You can join if…

Open to females ages 21 years and up

  • Planning to undergo or have undergone* RF ablation (Acessa) or myomectomy (laparoscopic or abdominal) for treatment of uterine fibroids.
  • Able to give informed consent
  • Speak English or Spanish
    • Women enrolled at contracted clinical sites must enroll prior to their RF ablation treatment

You CAN'T join if...

  • <21 years of age
  • Plan to undergo hysteroscopic myomectomy


  • UC Irvine Medical Center
    Irvine California 92868 United States
  • University of California, San Diego
    San Diego California 92037 United States


in progress, not accepting new patients
Start Date
Completion Date
University of California, San Francisco
Study Type
About 578 people participating
Last Updated