for people ages 18 years and up (full criteria)
at Irvine, California
study started
estimated completion
Principal Investigator
by Virginia Kimonis, MD



The researcher wants to explore the genetic causes of muscle disease. The researcher is particularly interested in muscle disorders that occur in combination with diseases of bone that appear to be passed on from generation to generation. Diffuse Optical Spectroscopy will measure the concentrations of blood, water, and lipids (fats, for example) in your tissues. This device essentially measures the color of tissues in order to determine tissue physiology (its physical and chemical processes).

Official Title

Phase 1 Study Non-invasive Use Diffuse Optical Spectroscopy Will Measure the Concentrations of Blood, Water, and Lipids (Fats, for Example) in Tissues


Diffuse Optical Spectroscopy, the technique is fast and painless and was developed at the University of California, Irvine. The Diffuse Optical Spectroscopy instrument is actively involved in research studies, but is not yet a part of routine clinical practice. The result of this study will aid similar research projects that seek to improve our understanding of how tissues work and how alterations in metabolism affect long-term health. TheDiffuse Optical Spectroscopy measurement consists of placing a probe onto the surface of your body (calf, bicep, or head). This probe will be secured by either gentle hand pressure or fastened to your skin using clinically-approved wraps such as Coban/wrap bandages or medical adhesive tape and medical glues. Several dots will be made on your skin outlining the probe with a surgical felt tip marker. This is so we would be able to put the probe again on the same spot in case we needed to interrupt the measurement. The probe looks like a bar code scanner in a supermarket and it shines infrared light on your skin. There is no radiation involved with this light. In some cases where light signals are low, the optical detector will be placed directly onto your skin (but contained within an electronically shielded casing, and placed inside another plastic casing). (not offered during pregnancy).


Muscle Disorder, Bone Disorder, muscle and bone disease, Bone Diseases, Muscular Diseases, Disease, Diffuse Optical Spectroscopy, Muscle weakness


You can join if…

Open to people ages 18 years and up

Male or Female age 18 and older

You CAN'T join if...

  • under 18 year of age
  • unrelated diagnosis


  • Beckman Laser Institute Medical clinic accepting new patients
    Irvine California 92612 United States

Lead Scientist at UC Irvine

  • Virginia Kimonis, MD
    Professor, Pediatrics, School of Medicine. Authored (or co-authored) 200 research publications


accepting new patients
Start Date
Completion Date
University of California, Irvine
Study Type
Expecting 25 study participants
Last Updated