Paroxysmal Nocturnal Hemoglobinuria clinical trials at UC Irvine
2 in progress, 0 open to eligible people
A Phase III Study Evaluating The Efficacy And Safety Of Crovalimab Versus Eculizumab In Adult And Adolescent Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Not Previously Treated With Complement Inhibitors.
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This study will enroll participants aged 12 years or older with a body weight >= 40 kg diagnosed with PNH who have not been previously treated with complement inhibitor therapy. Approximately 200 participants will be randomized in a 2:1 ratio into the following regimens: [1] Crovalimab; [2] Eculizumab.
Irvine, California and other locations
A Study Evaluating The Efficacy And Safety Of Crovalimab Versus Eculizumab In Adult And Adolescent Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors.
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A study designed to evaluate the non-inferiority of crovalimab compared with eculizumab in participants with PNH switching from eculizumab. This study will enroll approximately 250 participants randomized in a 1:1 ratio to the two arms.
Irvine, California and other locations
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