Paroxysmal Nocturnal Hemoglobinuria clinical trials at UC Irvine
2 in progress, 0 open to eligible people
A Phase III Study Evaluating The Efficacy And Safety Of Crovalimab Versus Eculizumab In Adult And Adolescent Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Not Previously Treated With Complement Inhibitors.
Sorry, not currently recruiting here
This study will enroll participants aged 12 years or older with a body weight >= 40 kg diagnosed with PNH who have not been previously treated with complement inhibitor therapy. Approximately 200 participants will be randomized in a 2:1 ratio into the following regimens: [1] Crovalimab; [2] Eculizumab.
Irvine, California and other locations
A Study Evaluating The Efficacy And Safety Of Crovalimab Versus Eculizumab In Adult And Adolescent Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors.
Sorry, not currently recruiting here
A study designed to evaluate the non-inferiority of crovalimab compared with eculizumab in participants with PNH switching from eculizumab. This study will enroll approximately 250 participants randomized in a 1:1 ratio to the two arms.
Irvine, California and other locations
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