Lumbar Spinal Stenosis clinical trials at UC Irvine

2 in progress, 1 open to eligible people

Showing trials for

  • MILD® Percutaneous Image-Guided Lumbar Decompression: a Medicare Claims Study

    open to eligible people ages 18 years and up

    This prospective longitudinal study will compare incidence rates of Medicare beneficiary surgical and minimally invasive intervention post index procedure, as well as harms associated with the MILD procedure, at 24 months post-treatment with MILD, tested against a control group of similar patients that have had a comparable procedure. This study will start with patients treated with a study procedure having an index date on or after January 1, 2017, and enrollment will continue until stopped by the sponsor.

    Santa Ana, California and other locations

  • Targeted Nutritional Supplement After Lumbar Spine Surgery: A Randomized, Placebo-Controlled, Double-Blind Trial

    Sorry, not yet accepting patients

    The goal of this clinical trial is to prospectively evaluate the effects of essential amino acid (EAA) supplementation on the volume and structure of the muscles surrounding the spine (paraspinal musculature). The main questions it aims to answer are: - Does EAA supplementation preserve paraspinal muscle volume (PMV) and influence changes to spinal alignment following lumbar spine surgery? - Does preserving paraspinal muscle volume (PMV) improve post-operative functional status? - Does preserving PMV reduce post-operative complications, pain, and opioid consumption? Participants will be asked to: - Consume either EAA supplement or placebo (alanine) twice daily for one week before and two weeks after lumbar spine surgery - Record pain levels and medication use in a diary - Perform functional assessments at routine follow-up visits after surgery - Undergo blood draws to monitor nutrition status and health - Undergo one spine magnetic resonance imaging (MRI) before surgery as part of routine surgical planning - Undergo one additional spine MRI after surgery to monitor PMV after treatment Researchers will compare the group that consumed EAA supplement and the group that consumed placebo to see if there is a difference in paraspinal muscle volume changes and measures of spinal alignment, functional abilities, pain levels, and opioid use.

    Orange, California

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