Kidney Transplant clinical trials at UC Irvine

5 in progress, 2 open to eligible people

Showing trials for

  • Learn How Safe and Tolerable Vonsetamig is in Adult Patients With Chronic Kidney Disease (CKD) Who Need Kidney Transplantation and Are Highly Sensitized to Human Leukocyte Antigen (HLA)

    open to eligible people ages 18-70

    The purpose of this study is to determine whether vonsetamig will safely decrease anti-HLA antibodies to allow for kidney transplantation. Vonsetamig is being studied for treatment of patients in need of kidney transplantation who are highly sensitized to HLA. The study is looking at several other research questions, including: - Side effects that may be experienced from taking vonsetamig - How vonsetamig works in the body - How much vonsetamig is present in the blood - If vonsetamig works to lower levels of antibodies to HLA

    Orange, California and other locations

  • Observational Extension Study for Adult Patients Treated in Study R5459-RT-1944 Who Receive a Kidney Transplant

    open to eligible people ages 18-70

    The main purpose of this study is to continue to see how vonsetamig works in the body and to monitor the outcomes after kidney transplant for participants previously treated in the R5459-RT-1944 study (NCT05092347). No study drug will be given during this study.

    Orange, California and other locations

  • Dietary Sodium Intake and Blood Pressure in Living Kidney Donors

    Sorry, currently not accepting new patients, but might later

    This is a pilot study to determine the feasibility of the study design and examine the main outcome whether low dietary sodium intake is superior to high dietary sodium intake in controlling blood pressure to be within the normotensive range in living kidney donors.

    Orange, California

  • Tegoprubart in Patients Undergoing Kidney Transplantation

    Sorry, in progress, not accepting new patients

    This study will evaluate the safety and efficacy of AT-1501 compared with tacrolimus in patients undergoing kidney transplantation.

    Orange, California and other locations

  • PROspera Kidney Transplant ACTIVE Rejection Assessment Registry (ProActive)

    Sorry, in progress, not accepting new patients

    The ProActive registry is a longitudinal, multi-center study with a prospective arm observing clinical care for patients receiving physician ordered Prospera, an allograft rejection test, and a historical control arm collecting data on cases at the same sites whose kidney allograft rejection status was managed with Serum Creatinine SCr/estimated Glomerular Filtration Rate eGFR. This registry will compare patient management and outcomes in patients who receive Prospera (Prospera arm) to the outcomes of the historical control group (control arm) to determine Prospera's clinical utility. High-risk subjects defined as having a biopsy-demonstrated rejection event or at least one pre-existing Donor Specific Antibody DSA with total Mean Fluorescent Intensity MFI>3000 or a calculated Panel Reactive Antibodies cPRA>70% will be followed for an additional period up to 24 months in both the Prospera arm and historical control arm.

    Irvine, California and other locations

Our lead scientists for Kidney Transplant research studies include .

Last updated: