Kidney Disease clinical trials at UC Irvine
5 in progress, 3 open to eligible people
Learn How Safe and Tolerable Vonsetamig is in Adult Patients With Chronic Kidney Disease (CKD) Who Need Kidney Transplantation and Are Highly Sensitized to Human Leukocyte Antigen (HLA)
open to eligible people ages 18-70
The purpose of this study is to determine whether vonsetamig will safely decrease anti-HLA antibodies to allow for kidney transplantation. Vonsetamig is being studied for treatment of patients in need of kidney transplantation who are highly sensitized to HLA. The study is looking at several other research questions, including: - Side effects that may be experienced from taking vonsetamig - How vonsetamig works in the body - How much vonsetamig is present in the blood - If vonsetamig works to lower levels of antibodies to HLA
Orange, California and other locations
VX-147 in Adult and Pediatric Participants With APOL1- Mediated Proteinuric Kidney Disease
open to eligible people ages 10-65
The purpose of this study is to evaluate the efficacy, safety, tolerability, and pharmacokinetics (PK) of VX-147 in adult and pediatric participants with apolipoprotein L1 (APOL1)-mediated proteinuric kidney disease.
Orange, California and other locations
Observational Extension Study for Adult Patients Treated in Study R5459-RT-1944 Who Receive a Kidney Transplant
open to eligible people ages 18-70
The main purpose of this study is to continue to see how vonsetamig works in the body and to monitor the outcomes after kidney transplant for participants previously treated in the R5459-RT-1944 study (NCT05092347). No study drug will be given during this study.
Orange, California and other locations
Human Acellular Vessel (HAV) With Fistulas as Conduits for Hemodialysis
Sorry, in progress, not accepting new patients
The main purpose of this study is to compare the Human Acellular Vessel (HAV) with arteriovenous fistula (AVF) when used for hemodialysis access
Irvine, California and other locations
Plant-Focused Nutrition in Patients With Diabetes and Chronic Kidney Disease
Sorry, accepting new patients by invitation only
In this pilot clinical trial, the investigators will recruit and randomize 120 patients with diabetes mellitus and chronic kidney disease (CKD/DM) stages 3 to 5 to a patient-centered and flexible Plant-Focused Nutrition in Diabetes (PLAFOND) diet with >2/3 plant-based sources, which will be compared with a standard-of-care CKD diet, which is usually a low-potassium and low-salt diet, over a 6-month period. Through this study, the investigators will determine whether the plant-focused diet intervention is feasible for patient adherence, whether this diet is safe by avoiding malnutrition, frailty, and high potassium or glucose blood levels, and whether patient reported outcomes are favorably impacted.
Orange, California and other locations
Last updated: