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Kidney Disease clinical trials at UC Irvine

8 in progress, 5 open to eligible people

Showing trials for
  • Adverse Events and Effectiveness of IntraVenous Infusions of ABBV-CLS-628 in Adult Participants With Autosomal Dominant Polycystic Kidney Disease (ADPKD)

    open to eligible people ages 18-55

    Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common genetic cause of kidney disease that causes fluid-filled cysts to develop in the kidneys. The purpose of this study is to assess the safety and efficacy of ABBV-CLS-628 for the treatment of ADPKD in adult participants. ABBV-CLS-628 is an investigational drug being developed for the treatment of ADPKD. Participants are placed in 1 of 4 groups, called treatment arms. Each group receives a different treatment. There is a 1 in 4 chance that participants will be assigned to placebo. Around 240 adult participants with ADPKD will be enrolled at approximately 100 sites worldwide. Participants will receive IntraVenous ABBV-CLS-628 or placebo every 4 weeks for 92 weeks. Participants will be followed for up to 15 weeks. There may be higher treatment burden for participants in this trial compared to their standard of care . Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.

    Orange 5379513, California 5332921 and other locations

  • Learn How Safe and Tolerable Vonsetamig is in Adult Patients With Chronic Kidney Disease (CKD) Who Need Kidney Transplantation and Are Highly Sensitized to Human Leukocyte Antigen (HLA)

    open to eligible people ages 18-70

    The purpose of this study is to determine whether vonsetamig will safely decrease anti-HLA antibodies to allow for kidney transplantation. Vonsetamig is being studied for treatment of patients in need of kidney transplantation who are highly sensitized to HLA. The study is looking at several other research questions, including: - Side effects that may be experienced from taking vonsetamig - How vonsetamig works in the body - How much vonsetamig is present in the blood - If vonsetamig works to lower levels of antibodies to HLA

    Orange 5379513, California 5332921 and other locations

  • TARPEYO® Treatment Beyond 9 Months in Adult Patients With Primary IgA Nephropathy

    open to eligible people ages 18 years and up

    The goal of this clinical trial is to assess the efficacy and safety of extended TARPEYO® (delayed-release budesonide capsules) treatment in adult patients with primary IgA nephropathy who have completed 9 months of TARPEYO® 16 mg once daily treatment in real-world clinical practice. The main question it aims to answer is: Is there a treatment benefit of TARPEYO® 16 mg QD extended use? Participants will - take part in this study for about 19 months - Have urine tests done - Have blood samples taken - Have physical examinations done

    Orange 5379513, California 5332921 and other locations

  • VX-147 in Adult and Pediatric Participants With APOL1- Mediated Proteinuric Kidney Disease

    open to eligible people ages 10-65

    The purpose of this study is to evaluate the efficacy, safety, tolerability, and pharmacokinetics (PK) of VX-147 in adult and pediatric participants with apolipoprotein L1 (APOL1)-mediated proteinuric kidney disease.

    Orange 5379513, California 5332921 and other locations

  • Extension Study for Adult Patients Treated in Study R5459-RT-1944 Who Receive a Kidney Transplant

    open to eligible people ages 18-70

    The main purpose of this study is to continue to see how vonsetamig works in the body and to monitor the outcomes after kidney transplant for participants previously treated in the R5459-RT-1944 study (NCT05092347). No study drug will be given during this study.

    Orange 5379513, California 5332921 and other locations

  • Human Acellular Vessel (HAV) With Fistulas as Conduits for Hemodialysis

    Sorry, in progress, not accepting new patients

    The main purpose of this study is to compare the Human Acellular Vessel (HAV) with arteriovenous fistula (AVF) when used for hemodialysis access

    Irvine 5359777, California 5332921 and other locations

  • Plant-Focused Nutrition in Patients With Diabetes and Chronic Kidney Disease

    Sorry, accepting new patients by invitation only

    In this pilot clinical trial, the investigators will recruit and randomize 120 patients with diabetes mellitus and chronic kidney disease (CKD/DM) stages 3 to 5 to a patient-centered and flexible Plant-Focused Nutrition in Diabetes (PLAFOND) diet with >2/3 plant-based sources, which will be compared with a standard-of-care CKD diet, which is usually a low-potassium and low-salt diet, over a 6-month period. Through this study, the investigators will determine whether the plant-focused diet intervention is feasible for patient adherence, whether this diet is safe by avoiding malnutrition, frailty, and high potassium or glucose blood levels, and whether patient reported outcomes are favorably impacted.

    Orange 5379513, California 5332921 and other locations

  • Tegoprubart in Patients Undergoing Kidney Transplantation

    Sorry, in progress, not accepting new patients

    This study will evaluate the safety and efficacy of AT-1501 compared with tacrolimus in patients undergoing kidney transplantation.

    Orange 5379513, California 5332921 and other locations

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