Chronic Kidney Disease clinical trials at UC Irvine
6 in progress, 3 open to eligible people
Learn How Safe and Tolerable Vonsetamig is in Adult Patients With Chronic Kidney Disease (CKD) Who Need Kidney Transplantation and Are Highly Sensitized to Human Leukocyte Antigen (HLA)
open to eligible people ages 18-70
The purpose of this study is to determine whether vonsetamig will safely decrease anti-HLA antibodies to allow for kidney transplantation. Vonsetamig is being studied for treatment of patients in need of kidney transplantation who are highly sensitized to HLA. The study is looking at several other research questions, including: - Side effects that may be experienced from taking vonsetamig - How vonsetamig works in the body - How much vonsetamig is present in the blood - If vonsetamig works to lower levels of antibodies to HLA
Orange 5379513, California 5332921 and other locations
TARPEYO® Treatment Beyond 9 Months in Adult Patients With Primary IgA Nephropathy
open to eligible people ages 18 years and up
The goal of this clinical trial is to assess the efficacy and safety of extended TARPEYO® (delayed-release budesonide capsules) treatment in adult patients with primary IgA nephropathy who have completed 9 months of TARPEYO® 16 mg once daily treatment in real-world clinical practice. The main question it aims to answer is: Is there a treatment benefit of TARPEYO® 16 mg QD extended use? Participants will - take part in this study for about 19 months - Have urine tests done - Have blood samples taken - Have physical examinations done
Orange 5379513, California 5332921 and other locations
Extension Study for Adult Patients Treated in Study R5459-RT-1944 Who Receive a Kidney Transplant
open to eligible people ages 18-70
The main purpose of this study is to continue to see how vonsetamig works in the body and to monitor the outcomes after kidney transplant for participants previously treated in the R5459-RT-1944 study (NCT05092347). No study drug will be given during this study.
Orange 5379513, California 5332921 and other locations
Human Acellular Vessel (HAV) With Fistulas as Conduits for Hemodialysis
Sorry, in progress, not accepting new patients
The main purpose of this study is to compare the Human Acellular Vessel (HAV) with arteriovenous fistula (AVF) when used for hemodialysis access
Irvine 5359777, California 5332921 and other locations
Plant-Focused Nutrition in Patients With Diabetes and Chronic Kidney Disease
Sorry, accepting new patients by invitation only
In this pilot clinical trial, the investigators will recruit and randomize 120 patients with diabetes mellitus and chronic kidney disease (CKD/DM) stages 3 to 5 to a patient-centered and flexible Plant-Focused Nutrition in Diabetes (PLAFOND) diet with >2/3 plant-based sources, which will be compared with a standard-of-care CKD diet, which is usually a low-potassium and low-salt diet, over a 6-month period. Through this study, the investigators will determine whether the plant-focused diet intervention is feasible for patient adherence, whether this diet is safe by avoiding malnutrition, frailty, and high potassium or glucose blood levels, and whether patient reported outcomes are favorably impacted.
Orange 5379513, California 5332921 and other locations
Tegoprubart in Patients Undergoing Kidney Transplantation
Sorry, in progress, not accepting new patients
This study will evaluate the safety and efficacy of AT-1501 compared with tacrolimus in patients undergoing kidney transplantation.
Orange 5379513, California 5332921 and other locations
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