for people ages 18 years and up (full criteria)
at Los Angeles, California and other locations
study start
estimated completion



This study is to prospectively compare clinical effectiveness between clinically- matched incremental hemodialysis and conventional hemodialysis in patients with incident kidney dysfunction requiring dialysis and residual kidney function.

Official Title

Comparative Effectiveness of an Individualized Model of Hemodialysis Versus Conventional Hemodialysis


This study will analyze the effects of differentiated care with individualized hemodialysis on patient health related quality of life, fatigue, employment, and caregiver burden in patients with Kidney dysfunction requiring dialysis (KDRD) and appreciable kidney function.

This study will compare the outcomes in survival, hospitalization, preservation of the kidney function and quality of life between hemodialysis tailored to each patient needs (incremental) and conventional hemodialysis.


End-Stage Kidney Disease, Hemodialysis, Clinically-Matched Incremental Hemodialysis, Kidney Diseases, Chronic Kidney Failure, Hemodialysis twice weekly, Hemodialysis thrice weekly, Clinically-matched Incremental Hemodialysis ( CMIHD)


For people ages 18 years and up

Patient eligibility Criteria:

Inclusion Criteria:

  • Clinical Inclusion Criteria:
  • Age ≥ 18 years
  • Incident kidney dysfunction requiring dialysis (KDRD) started on maintenance, in-center hemodialysis (HD), or anticipated to be started on maintenance, in-center HD within the next 6 weeks
  • Has received ≤18 sessions of intermittent HD (i.e., on HD for ≤6 weeks) at the time patient is approached for potential study participation

Residual Kidney Function Inclusion Criteria:

  • Kidney urea clearance# ≥3.5 mL/min/1.73 m2
  • Urine volume# of ≥500 mL/24 h

Exclusion Criteria:

  • Pre-HD serum K ≥5.8 mEq/L, Na ≤125 mEq/L, or bicarbonate level ≤17 mEq/L
  • Requirement or anticipated requirement of high-volume ultrafiltration
  • Unable or unwilling to follow the study protocol for any reason
  • Known pregnancy or planning to attempt to become pregnant or lactating women
  • Estimated survival or dialysis modality change or center transfer <6 months

Caregiver Eligibility Criteria:

  • be at least 18 years old
  • be the main caregiver (at patient's choice)
  • be a close relative of the patient (spouse, child, sibling, parent, grandchild)
  • have no known psychiatric and neurologic disorders (through direct inquiry from the person)
  • not be a member of the medical or healthcare team
  • not be the caregiver for another patient with chronic illness
  • not have experienced severe life events within prior 3 months of enrollment (through direct inquiry from the person)


  • UCLA
    Los Angeles California 90095 United States
  • Harbor University of California Los Angeles
    Torrance California 90509 United States


not yet accepting patients
Start Date
Completion Date
Wake Forest University Health Sciences
Study Type
Expecting 350 study participants
Last Updated