for people ages 18 years and up (full criteria)
at Orange, California and other locations
study started
estimated completion



The purpose of this first-in-patient, open label study is to determine the maximum tolerated dose and/or recommended dose for further study of PF-07284892 as a single agent and in combination with lorlatinib, encorafenib and cetuximab, or binimetinib and evaluate the pharmacokinetics, safety, and preliminary clinical activity of single agent and each combination therapy.

Official Title

A Phase 1 Open-Label, Multi-Center, Dose Escalation and Dose Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Evidence of Antitumor Activity of PF-07284892 (ARRY-558) as a Single Agent and in Combination Therapy in Participants With Advanced Solid Tumors


Solid Tumor colorectal cancer non-small cell lung cancer B-type Raf proto-oncogene (BRAF) mutation Ras mutation anaplastic lymphoma kinase (ALK)-positive neurofibromatosis type 1 (NF1) ROS1 Neoplasms Cetuximab lorlatinib binimetinib encorafenib PF-07284892 monotherapy


You can join if…

Open to people ages 18 years and up

  • Age ≥18 years at the time of informed consent
  • Histological or cytological diagnosis of ALK-positive advanced NSCLC, CRC with BRAF V600E mutation, or RAS- mutant, NF1-mutant or BRAF class 3 mutant solid tumor. Participants with ROS-positive NSCLC are also eligible for Part 1 and 2
  • Documentation evidence of biomarker mutation status
  • Part 3:

ALK-positive NSCLC with prior lorlatinib and no prior platinum-based chemotherapy (Cohort 1); with prior lorlatinib and prior platinum-based chemotherapy (Cohort 2); or with no prior lorlatinib (Cohort 3).

BRAF V600E mutant CRC participants resistant to BRAFi plus EGFRi (Cohort 4 ); refractory to BRAFi plus EGFRi (Cohort 5); or BRAFi plus EGFRi naïve (Cohort 6).

RAS- mutant, NF1-mutant or BRAF class 3 mutant solid tumors who have received prior SOC (Cohort 7).

You CAN'T join if...

  • Brain metastasis larger than 4 cm
  • Active malignancy within 3 years
  • Systemic anti-cancer therapy or small molecule therapeutics within 2 weeks prior to start of study treatment. Antibody based agents within 4 weeks prior to start of study treatment. Mitomycin C or nitrosoureas within 6 weeks prior to start of study treatment.
  • For participants who may get lorlatinib or encorafenib on study, history of interstitial lung disease
  • For participants who may get binimetinib on study, history or current evidence of retinal vein occlusion (RVO) or concurrent neuromuscular disorder associated with elevated creatine kinase (CK)


  • UC Irvine Health accepting new patients
    Orange California 92868 United States
  • The University of Texas MD Anderson Cancer Center accepting new patients
    Houston Texas 77030 United States


accepting new patients
Start Date
Completion Date
To obtain contact information for a study center near you, click here.
Phase 1
Study Type
Last Updated