Summary

Eligibility
for people ages 18 years and up (full criteria)
Location
at Fountain Valley, California and other locations
Dates
study started
estimated completion

Description

Summary

This study will assess the antitumor activity, safety, tolerability, and pharmacokinetics (PK) of the Mesenchymal-epithelial Transition Factor (MET) inhibitor tepotinib combined with the 3rd generation EGFR inhibitor osimertinib in participants with advanced or metastatic non-small cell lung cancer (NSCLC).

Official Title

A Phase II, Two-arm Study to Investigate Tepotinib Combined With Osimertinib in MET Amplified, Advanced or Metastatic NSCLC Harboring Activating EGFR Mutations and Having Acquired Resistance to Prior Osimertinib Therapy (INSIGHT 2)

Keywords

Non-small Cell Lung Cancer Tepotinib Osimertinib INSIGHT 2 MET amplified Carcinoma, Non-Small-Cell Lung Tepotinib and Osimertinib Tepotinib Mono-therapy

Eligibility

You can join if…

Open to people ages 18 years and up

  • Locally advanced or metastatic Non-small Cell Lung Cancer (NSCLC) histology (confirmed by either histology or cytology) with documented activating Epidermal Growth Factor Receptor (EGFR) mutation
  • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 and a minimum life expectancy of 12 weeks
  • Acquired resistance on previous first-line osimertinib. Participants must meet both of the following 2 criteria:
  • Radiological documentation of disease progression on first-line osimertinib
  • Objective clinical benefit documented during previous osimertinib therapy, defined by either partial or complete radiological response, or durable stable disease (SD) (SD should last greater than (>) 6 months after initiation of osimertinib
  • Have received only first-line osimertinib as a prior line of therapy in the non curative advanced or metastatic NSCLC setting
  • MET amplification as determined by either FISH testing (central or local) on tumor tissue (TBx) or central blood-based next generation sequencing (LBx). Tumor and blood samples must be collected following progression on prior first-line osimertinib at Prescreening
  • Submission of tumor tissue and blood sample obtained after progression on first-line osimertinib, is mandatory for all patients for MET amplification testing
  • Submission of tumor tissue during Prescreening or Screening is mandatory for patients with tumor tissue tested by local FISH, to confirm MET amplification status. Central confirmation is not mandated prior to the start of study treatment
  • Other protocol defined inclusion criteria could apply

You CAN'T join if...

  • Spinal cord compression or brain metastasis unless asymptomatic, stable or not requiring steroids for at least 2 weeks prior to start of study intervention
  • Any unresolved toxicity Grade 2 or more according to National cancer institute common terminology criteria for adverse events( NCI-CTCAE) version 5, from previous anticancer therapy with the exception of alopecia
  • Inadequate hematological, liver and renal function
  • Impaired cardiac function
  • History of interstitial lung disease(ILD) or interstitial pneumonitis including radiation pneumonitis that required steroid treatment
  • Hypertension uncontrolled by standard therapies (not stabilized to < 150/90 millimeter of mercury (mmHg)
  • Contraindication to the administration of osimertinib
  • Other protocol defined exclusion criteria could apply.

Locations

  • Compassionate Care Research Group Inc - Edinger Medical Group, Inc. currently not accepting new patients, but might later
    Fountain Valley California 92708 United States
  • Chao Family Clinical Research Center - RC for Dr. Kenneth Chang not yet accepting patients
    Orange California 92868 United States

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
EMD Serono Research & Development Institute, Inc.
Links
Trial Awareness and Transparency website US Medical Information website, Medical Resources Targeting MET Clinical Trial Program
ID
NCT03940703
Phase
Phase 2
Study Type
Interventional
Last Updated