Complication of Personal Oral Hygiene clinical trials at UC Irvine
1 research study open to eligible people
open to eligible people ages 18 years and up
There is a need for toothpastes that more effectively remove oral biofilm, and inhibit biofilm re-formation. This is particularly important for patients with long-term orthodontic fixtures or prosthodontic appliances, and also for debilitated, diabetic and immunocompromised patients. The objective of this study is to evaluate the effects of toothpastes on plaque presence and removal, dental hard tissue mineralization, erosion, abrasion and microstructure as well as gingival and periodontal health and dry/sore mouth. In addition to clinical scoring and photographs, measurements of tooth and gum sensitivity, saliva volume, pH and buffering, variables may be evaluated using tooth samples worn on removable dental retainers. These samples will be examined outside of the mouth using advanced optical techniques such as Optical Coherence Tomography (OCT), Fluorescence, various forms of microscopy and spectroscopy.